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Molecular Inversion Probes for targeted resequencing in non-model organisms

Molecular Inversion Probes for targeted resequencing in non-model organisms

Few methods for medium-scale targeted resequencing are available for non-model organisms We explored the utility and demonstrated good performance of Molecular Inversion Probes (MIPs) in a non-model system possessing a very large and complex genome. MIP markers have numerous advantages: high specificity, high multiplexing level, low sample requirement, straightforward laboratory protocol, no need for genomic libraries and no ascertainment bias. MIP markers are thus a useful extension of the molecular toolkit and an effective solution for large-scale resequencing of tens or hundreds of kb in ecological and evolutionary studies.

https://www.nature.com/articles/srep24051

and

http://www.molecularecologist.com/2016/07/molecular-inversion-probes-phylogenomics-without-the-excess/